Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation
نویسندگان
چکیده
منابع مشابه
Soluble St2 Blocks Il-33 Signaling in Allergic Airway Inflammation
SOLUBLE ST2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION Hiroko Hayakawa1, Morisada Hayakawa1, Akihiro Kume2, and Shin-ichi Tominaga1 From the 1Department of Biochemistry and 2Division of Genetic Therapeutics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan Running Title: Suppression of IL-33 signaling by soluble ST2 Address correspondence to: Moris...
متن کاملPollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation
Innate immunity has been extended to respond environmental pathogen other than microbial components. Here we explore a novel pollen/TLR4 innate immunity in allergic inflammation. In experimental allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated IL-33/ST2 signaling and overproduced Th2 cytokine were observed in ocular surface, cervical lymph nodes ...
متن کاملIL-33/ST2 signaling boosts inflammation and pain.
We read with interest the work of Taracanova et al. (1) on the synergic effect of substance P (SP) and IL33 over TNF-α production. Notably, IL-33 potentiates SP-induced TNF-α production by more than 100-fold in mast cells. Both IL-33 and SP increase the expression of each other receptor, and more interestingly, ST2 coimmunoprecipitates with neurokinin-1 (NK-1, SP receptor), demonstrating a form...
متن کاملSoluble ST2 suppresses the effect of interleukin-33 on lung type 2 innate lymphoid cells
Type 2 innate lymphoid cells (ILC2) in lungs produce interleukin (IL)-5 and IL-13 in response to IL-33 and may contribute to the development of allergic diseases such as asthma. However, little is known about negative regulators and effective inhibitors controlling ILC2 function. Here, we show that soluble ST2, a member of the IL-1 receptor family, suppresses the effect of IL-33 on lung ILC2 in...
متن کامل[Interleukin-33/ST2: a new signaling pathway in immunity and immunopathology].
Toll like receptors (TLR) čine familiju transmembranskih signalnih proteina koji delujući kao senzori za produkte mikroorganizama započinju antimikrobni imunski odgovor. Do danas, kod sisara je poznato 12 TLR gena koji kodiraju isto toliko membranskih glikoproteina sa ekstracelularnim delom bogatim leucinom i intercitoplazmatskim delom sa homologijom (TIR). Toll-IL-1 receptor (TIR) domen sadrži...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m704916200